Which of the following are possible B cell markers?

Prepare for the ACVIM General Board Exam with comprehensive flashcards and in-depth multiple choice questions. Gain insights with detailed explanations and enhance your readiness for success!

B cell markers are specific proteins expressed on the surface of B cells that are important for their identification and function. The correct choice includes CD21, CD45, and CD79, which are all well-established markers of B cells.

CD21 is a receptor for complement component C3d and is involved in B cell activation and proliferation. It plays a crucial role in enhancing the B cell response to antigens. CD45 is a common leukocyte antigen that is important for cell signaling and acts as a marker to distinguish between different mature and activated B cell populations. CD79 is a component of the B cell receptor complex, which is essential for signal transduction in B cells following antigen engagement.

The other sets of markers listed do not specifically reflect B cell identification or function and are more characteristic of other immune cell lineages. For example, CD4 and CD8 are T cell markers, while CD14 is associated with monocytes. CD34 is typically a marker of hematopoietic stem cells rather than mature B cells. Understanding the specific markers that denote different cell types helps in accurately diagnosing and managing immune-related conditions.

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