What type of cell is responsible for presenting antigens to naive T cells?

Dendritic cells are considered the most important antigen-presenting cells (APCs) for naive T cells. Their primary role in the immune system is to capture and process antigens, then present these antigens on their surface bound to major histocompatibility complex (MHC) molecules. This interaction between dendritic cells and naive T cells is crucial for initiating T cell responses, as it provides the necessary signals for T cell activation and differentiation.

Dendritic cells are strategically located throughout tissues where they can intercept pathogens and other antigens. Once they capture an antigen, they migrate to the lymph nodes, where they effectively present the processed antigen to naive T cells. This process is fundamental to establishing a robust adaptive immune response.

While B cells and macrophages can also present antigens, dendritic cells are typically more effective due to their ability to activate naive T cells directly. Neutrophils, on the other hand, primarily function in the innate immune response, and while they can contribute to antigen presentation, they are not specialized for this role and do not present antigens to naive T cells effectively.