What part of the cell does lupus predominantly attack?

Lupus, particularly systemic lupus erythematosus (SLE), predominantly attacks the nucleus of cells. This autoimmune disorder triggers the body’s immune system to produce antibodies against its own nuclear components, such as DNA, RNA, and various nuclear proteins. The presence of these antibodies can lead to inflammation and damage in various tissues and organs. This is particularly significant because the nucleus contains the genetic material and is pivotal for regulating cell functions, including growth and replication.

By understanding that the nucleus is the primary target, one can better grasp the implications of autoimmune responses, such as the development of symptoms that can affect multiple organ systems, as seen in lupus. Other cellular components, like the cytoplasm, cell membrane, or mitochondria, do not have the same direct association with the autoimmune response seen in lupus, which specifically emphasizes the involvement of nuclear elements.