What glomerular disease is unlikely to improve with prednisone treatment?

Glomerular sclerosis typically results from chronic injury to the kidneys and usually indicates significant scarring of the glomeruli. This condition signifies advanced disease with irreversible damage, which makes it less responsive to treatments like prednisone that are effective in treating inflammation and immune-mediated damage. Prednisone, a corticosteroid, is typically utilized to manage glomerular diseases that have an inflammatory or immune basis, which leads to alterations in glomerular function.

Other conditions listed can often show improvement with corticosteroid treatment, particularly minimal change disease and focal segmental glomerulosclerosis, as they may still retain some functional reserve and exhibit inflammatory processes that can be modulated by steroids. IgA nephropathy can also sometimes respond to steroid treatment, especially in cases that present with significant nephritic features or deterioration in kidney function. However, once significant glomerular sclerosis is established, the potential for improvement with prednisone is markedly diminished, as the underlying pathology is more related to scarring and reduced renal function rather than active inflammation.