What condition is associated with a history of recurrent infections and elevated WBC count in a young dog?

Canine leukocyte adhesion deficiency (CLAD) is a genetic condition that impacts the ability of white blood cells (WBCs) to migrate to sites of infection. In affected dogs, there is a defect in the CD18 protein, which is essential for the formation of integrins on the surface of leukocytes. These integrins are necessary for the adherence of white blood cells to the endothelium of blood vessels, allowing them to exit the bloodstream and reach tissues where they are needed for immune responses.

As a result, dogs with CLAD often experience recurrent infections due to their impaired immune response. Despite having an elevated WBC count, the white blood cells present are unable to effectively reach the sites of infection and mount an appropriate immune response. This leads to the characteristic presentations of frequent infections and the elevated WBC count observed in these dogs.

The other conditions listed typically do not present with this specific combination of signs. For example, hypothyroidism does not primarily cause recurrent infections or elevated WBC counts, while canine leukemia involves neoplastic changes in the white blood cells, which could manifest differently. Immune-mediated hemolytic anemia is primarily characterized by the destruction of red blood cells and would not typically be associated with recurrent infections as a primary